THECA Programme
THECA programme is to:
- Conduct a Typbar-TCV® Phase 3 cluster-randomized trial to measure population-level vaccine protection in Ghana
- Conduct a Typbar-TCV® mass-vaccination campaign with a nested case-control study to measure vaccine protection under realistic public health conditions in the Democratic Republic of Congo
- Generate data on mass-campaign feasibility, cost-effectiveness, safety, immunogenicity and impact on antimicrobial resistance
- Enhance capacity building for conducting the clinical trials in Africa
- Support regulatory affairs for TCV introduction in Ghana, Democratic Republic of Congo, Madagascar, and Burkina-Faso
Goals
THECA Programme will fill a large gap in ongoing large-scale typhoid control efforts
Commitment
Generate critical data to enable African and international policymakers to make informed decisions on TCV introductions